eliquis rash pictures eliquis rash pictures

But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. If you do need to stop treatment with Eliquis, your doctor may recommend that you take a different blood thinner. Before having surgery or any medical/dental procedures (especially spinal puncture or spinal/epidural anesthesia), tell your doctor or dentist that you are taking this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). US residents can call their local poison control center at 1-800-222-1222. Data obtained from you in connection with your registration for, and use of, this service may include your phone number and related carrier information. You should continue taking Eliquis for as long as your doctor recommends. If youve had an allergic reaction to Eliquis or any of its ingredients, your doctor will likely not prescribe Eliquis. But in studies, nosebleeds were not a commonly reported side effect in people taking Eliquis. Ask your doctor what other medications may be better options for you. They alert doctors and patients about drug effects that may be dangerous. Examples of the blood clots Eliquis treats include deep vein thrombosis (DVT) and pulmonary embolism (PE). We present a case of probable rivaroxaban-induced rash. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. The two companies were testing Eliquis, which includes apixaban, an orally-taken inhibitor which blocks a key blood-clotting protein, reducing the risk of thrombin generation and blood clots. There are many possible triggers of these digestive problems. Since Eliquis can also cause bleeding, drinking alcohol while taking Eliquis may further increase your risk of bleeding. If youre pregnant or breastfeeding, or planning to become pregnant or breastfeed, talk with your doctor. You should avoid drinking large amounts of alcohol while taking Eliquis. This is a list of some of the serious side effects of ELIQUIS. You can stop taking Eliquis without tapering your dosage first. Tell your doctor if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. Spinal and epidural injections are used to administer medication such as pain relievers or anesthesia into your spinal cord. What should I do if I become pregnant during Eliquis treatment? ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation, a type of irregular heartbeat, not caused by a heart valve problem. You are being redirected to a Pfizer corporate site. You can learn more about how we ensure our content is accurate and current by reading our. Poison oak rash can produce a severe, painful rash. Links to other sites are provided only as a convenience to users of this site. If you accidentally unsubscribe, or your mobile number changes, you may re-enroll in the mobile program via the method by which you may have originally enrolled. Females who are able to become pregnant: talk with your healthcare provider about pregnancy planning, and your risk of severe uterine bleeding if you are treated with blood thinner medicines, including ELIQUIS. Diarrhea has also been reported with a different type of blood thinner called Jantoven (warfarin). This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. If you develop serious side effects while taking Eliquis, call your doctor right away. Its not known if it may be safe to take Eliquis during pregnancy or while breastfeeding. Possible serious side effects include bleeding or a reaction to ELIQUIS itself. You are about to leave the Bristol Myers Squibb and Pfizer ELIQUIS.com site. Ask your doctor about the benefits and risks before any spinal procedure. Many people using this medication do not have serious side effects. Do not store in the bathroom. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. As with many medications, higher dosages of Eliquis are more likely to cause side effects than lower dosages. However, if you stop Eliquis sooner than your doctor recommends, you may have an increased risk of blood clots. Message and data rates may apply. If youd like to learn more about Eliquis, talk with your doctor or pharmacist. Applying an ice pack can also help to stop minor bleeding. Is exercise more effective than medication for depression and anxiety? You may have a higher risk of bleeding if you take blood thinners and take other medicines that increase your risk of bleeding. Side effects arent common with Eliquis. Your risk of developing a spinal or epidural blood clot is higher if: a thin tube called an epidural catheter is placed in your back to give you certain medicine, you take NSAIDs or a medicine to prevent blood from clotting, you have a history of difficult or repeated epidural or spinal punctures, you have a history of problems with your spine or have had surgery on your spine. You should not do both. At the hospital, you may be given intravenous steroids and hydration. People with triple-positive APS may have an increased risk of blood clots from Eliquis. If you stop taking this medication early, you have a higher risk of forming a serious blood clot (such as a stroke, blood clot in the legs/lungs). Taking a blood thinner as part of your AFib treatment can reduce your risk of blood clots and stroke. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming. Most bleeding is minor (see above), but sometimes bleeding can be serious or even life threatening. Is my risk of side effects increased due to other medications that Im taking? While taking Eliquis, you should be extra careful with activities that could cause a cut, injury, or bleeding. Eliquis (apixaban) tablets, for oral use. Last medically reviewed on July 21, 2022. Platelets usually help your blood to clot. Eliquis has a boxed warning for this side effect. Having certain spinal procedures during Eliquis treatment may increase the risk of blood clots in your spine. The other is about the increased risk of blood clots if Eliquis treatment is stopped early. If you have a spinal blood clot, your doctor will give you medication to treat this as soon as possible. Eliquis is unlikely to cause long-term side effects. For patients taking ELIQUIS for atrialfibrillation: stopping ELIQUIS increases your risk of having a stroke. Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS: Spinal or epidural blood clots (hematoma). Side effects of Eliquis typically get better after you stop taking the medication. Eliquis hasnt been reported to cause kidney-related side effects, such as kidney damage or reduced kidney function. * This clot may press on your spinal cord, which could cause long lasting or permanent paralysis. The ELIQUIS (apixaban) Starter Kit (PDF), The ELIQUIS (apixaban) Dosing Guide (PDF), The ELIQUIS (apixaban) Discussion Guide (PDF). During your Eliquis treatment, consider taking notes on any side effects youre having. A boxed warning is a serious warning from the Food and Drug Administration (FDA). All rights reserved. If you drink alcohol, talk with your doctor about how much is safe to consume while taking Eliquis. Bleeding that is severe oryou cannotcontrol, You have a history of difficult or repeated epidural or spinal punctures, currently have certaintypes of abnormalbleeding, You may have a higher risk of bleeding if you take. First a patch on my foot that appeared to be ringworm and did actually respond to ringworm creams, but did not clear up and is still here. If you have one of these spinal procedures while taking Eliquis, this could cause a spinal or epidural hematoma (blood clot in your spine). ELIQUIS is available in two different tablets. The studies did not find an increased risk of Eliquis side effects in older people when compared with younger people. For example, you may have internal bleeding in your digestive system, lungs, brain, liver, kidneys, abdominal cavity, joints, or eyes. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Eliquis has a boxed warning for the risk of spinal blood clots with spinal procedures. 4. This website is best viewed using the vertical display on your mobile device. Another rare side effect of Eliquis is blood in the urine, which could be due to a kidney-related problem. Constipation and diarrhea have been reported with certain other blood thinners in the same class as Eliquis, such as Xarelto (rivaroxaban). Learn more about some of the side effects Eliquis may cause. So Eliquis is currently not recommended for use during pregnancy. Learn about risks, signs to contact a doctor, and more. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Other drugs that have the same active ingredients (e.g. Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you. Also, drug rashes dont tend to cause any other symptoms. I developed a rash , red, itchy on my back after starting Eliquis. In studies, the majority of people taking Eliquis were ages 65 years and older. If you have liver problems, Eliquis may build up in your body. Before you start treatment with Eliquis, talk with your doctor about the possible side effects of this medication. You may have nosebleeds during your treatment with Eliquis. If you have any of the symptoms listed above, contact your doctor or go to a hospital right away. Its recommended that you do not stop taking Eliquis without first talking with your doctor. They can discuss your risk of side effects with you. In some cases, they may recommend a different medication. See more about possible serious side effects. You are insured by commercial insurance and your prescription insurance coverage does not cover the full cost of your prescription, that is,you have a, You do not have prescription insurance coverage through a state or federal healthcare program, including but not limited to Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), or Department of Defense (DOD). This causes swelling in the form of a hematoma. Bleeding in this area can cause paralysis that lasts a long time or could become permanent. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. The risk of bleeding may be higher if you have a deformed spine, or have had spinal procedures/surgery before (such as epidural catheter placement, difficult epidural/spinal puncture), or are taking other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/enoxaparin, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Eliquis will likely make the bleeding worse. With atrial fibrillation, part of the heart does not beat the way it should. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Do not stop taking apixaban unless directed by your doctor. If your kidneys arent working properly, this medication can build up in your body. For example, you may consider: Additionally, you should tell any healthcare professionals who treat you that youre taking Eliquis. If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Learn more below. You may also consider discussing other risk factors with your doctor: Drug rashes may go away on their own once you stop taking the drug that caused your rash. If you notice other effects not listed above, contact your doctor or pharmacist. Warfarin-induced skin necrosis affects one in every 10,000 patients prescribed warfarin. We avoid using tertiary references. Apixaban is an anticoagulant that works by blocking certain clotting proteins in your blood. A drug allergy is an allergic reaction to a medication. Certain blood thinners, such as warfarin, can cause anticoagulant-induced skin necrosis. Properly discard this product when it is expired or no longer needed. Discover 6 frequently asked questions about blood thinners and alcohol, answered by an expert. Symptoms of blood clots in your spine include: Before having any spinal procedures done, tell your doctor that youre taking Eliquis. However, the exact timeline also depends on the type of rash you have, as well as the severity. Eliquis (apixaban) tablets, for oral use (2021). Before you start taking this drug, tell your doctor about any bleeding disorder you have. A head injury could cause bleeding inside your skull or in your brain while youre taking Eliquis. Before taking Eliquis, there are certain precautions to consider. Consult your pharmacist or local waste disposal company. If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. ELIQUIS is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery. Additional symptoms are severe and can involve the internal organs, such as: Possible drugs that can cause DRESS include: DRESS is a very serious reaction that requires immediate medical attention. People who take ELIQUIS, and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). No, older people do not seem to have a higher risk of side effects from Eliquis than younger people. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Adverse drug reactions and organ damage: The skin. If it is near the time of the next dose, skip the missed dose. Selected from data included with permission and copyrighted by First Databank, Inc. Examples of drugs that can cause erythroderma, including: Certain underlying health conditions can also cause erythroderma, such as psoriasis and atopic dermatitis. What should I know regarding pregnancy, nursing and administering Eliquis to children or the elderly. As with other drugs, Eliquis can cause side effects (also known as adverse effects). Withdrawal symptoms are side effects that can occur if you stop taking a drug that your body relies on. The list below may not include all possible serious side effects of the drug. hopkinsmedicine.org/healthlibrary/conditions/dermatology/drug_rashes_85,P00280, ejinme.com/article/S0953-6205(15)00414-8/fulltext, aaaai.org/tools-for-the-public/conditions-library/allergies/medications-and-drug-allergic-reactions, fda.gov/drugs/resourcesforyou/specialfeatures/ucm464195.htm, How to Recognize and Get Help for Hypersensitivity Syndrome, Overview of Purpuric Rash, a Symptom of Some Conditions, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, How to Get Rid of Dark Circles Permanently, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. Do not double the dose to catch up. Post author By ; Post date surclassement gp air france; raspberry pi zero w datasheet . If youre concerned about the risk of side effects with the dosage of Eliquis your doctor has prescribed, talk with your doctor. [Text HELP to 69108 for help.] While any drug can cause a rash, certain types are more notorious for causing reactions. See below for more important safety information about ELIQUIS. Its not known if Eliquis may be present in breast milk or may have an effect on a child who is breastfed. You shouldnt stop taking Eliquis suddenly without talking with your doctor. However, home remedies could help, like apple cider vinegar and tea tree oil. Eliquis has a boxed warning for the risk of spinal blood clots with spinal procedures. Seek immediate medical attention if you think this is the type of rash you have. Apixaban may increase the risk of bleeding in the pregnant woman, the unborn baby, and the newborn baby. To learn more about conditions that can affect the safety of Eliquis, see the Precautions for Eliquis section below. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. And some may be easily managed. All rights reserved. In clinical trials, minor bleeding was the most common side effect reported with Eliquis. This has important therapeutic implications, as premature discontinuation of clopidogrel is the strongest risk factor for stent thrombosis. No, you shouldnt experience withdrawal symptoms if you stop taking Eliquis suddenly. WebMD does not provide medical advice, diagnosis or treatment. Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack ), recent stroke, or blood circulation disease (peripheral vascular disease).It is also . Depending on what youre using Eliquis for, you may take it short term or long term. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Territory. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements. Theyll discuss whether Eliquis may be a safe treatment option for you. Drug rashes can appear as a variety of skin rashes, including pink to red bumps, hives, blisters, red patches, pus-filled bumps (pustules), or sensitivity to sunlight. You are encouraged to report negative side effects of prescription drugs to the FDA. ELIQUIS (apixaban) is a prescription medicine used to reduce the risk, ELIQUIS (apixaban) is a prescription medicine used to treat blood clots, This is a summary of important safety information that you need, Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you. Bristol Myers Squibb and Pfizer are not responsible for the content of such other sites and shall not be liable for any damages or injury arising from users access to such sites. Some people may experience mild to serious side effects during their Eliquis treatment. 1-800-FDA-1088. For people taking ELIQUIS (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Your skin may grow scaly within several days. The dosage is based on your medical condition, age, weight, kidney function, response to treatment, and other medications you may be taking. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Feeling of warmth on the skin. Symptoms can be mild to serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Keep all medications away from children and pets. But older people are more likely to have medical conditions than younger people. 106th field artillery; mobile homes for rent silver creek, ga; pump spare parts list; owo bot discord gems; zephyr exhaust fan turns on by itself; narcissist hoover trigger Medications and drug allergic reactions. Most of these are related to bleeding, since the drug reduces the bloods ability to form clots. Be sure to talk with your doctor about your health history before you take Eliquis. As with most drugs, Eliquis can cause an allergic reaction in some people. You can learn more about how we ensure our content is accurate and current by reading our. You should also call your doctor right away if you fall and hit your head or have any other kind of head injury. For more information on this boxed warning, see the Side effects explained section below. Summary: After starting rivaroxaban for treatment of cancer-associated deep vein thrombosis (DVT) with pulmonary embolism (PE), a 69-year-old Caucasian woman arrived at an oncology clinic with a diffuse, exanthematous (morbilliform) rash on her neck . While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop. You may not notice symptoms of DRESS for 2 to 6 weeks after starting a new drug. Talk with your doctor about how long you should take Eliquis. Eliquis has a boxed warning for this risk. Call your doctor for medical advice about side effects. The product information provided in this site is intended only for residents of the United States. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have concerns about risk of spinal blood clots during Eliquis treatment, talk with your doctor or pharmacist. This medication may cause stomach bleeding. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Keep all medical and lab appointments. Your doctor will monitor you for symptoms of spinal blood clots after the procedure. Having certain medical conditions may increase the risk of side effects from taking Eliquis. Do not share this medication with others. As such, the most common side effects of Eliquis include: Bleeding Bruising more easily than normal Anemia Other common side effects of Eliquis may include: Allergic reaction (skin rash, itching, flushing) Fatigue Nausea Headaches Dizziness To learn more about this, see Side effect specifics below. What are the more common side effects of Eliquis? Tell your healthcare team about all the medicines you take, including any: During treatment, make sure you talk to your healthcare team before you begin to take any newmedication. This medication is a blood thinner and increases your risk of bleeding. 1-800-FDA-1088. More severe drug rashes, such as erythroderma, may cause permanent changes to skin pigmentation after treatment. Serious side effects that have been reported with Eliquis include: * For more information about this side effect, see Side effect specifics below. [For questions about the Program, call. Should I avoid certain foods while taking Eliquis? ELIQUIS may need to bestopped before surgery or a medical or dental procedure. This clot may press on your spinal cord, which could cause long lasting or even permanent paralysis. You may be eligible for the Co-pay Card for ELIQUIS (apixaban) if: Questions can also be submitted via mail to: BY USING THIS CARD, YOU AND YOUR PHARMACIST UNDERSTAND AND AGREE TO COMPLY WITH THESE ELIGIBILITY REQUIREMENTS AND TERMS OF USE. In the US - Call your doctor for medical advice about side effects. One is about the risk of spinal blood clots with spinal procedures. Tell your doctor right away if you have any signs of serious bleeding, including: nosebleeds that happen often or don't stop, unusual tiredness/weakness, unusual pain/swelling/discomfort, unusual bruising, prolonged bleeding from cuts or gums, unusually heavy/prolonged menstrual flow, pink/dark urine, coughing up blood, vomit that is bloody or looks like coffee grounds, severe headache, dizziness/fainting, bloody/black/tarry stools, difficulty swallowing. Tell your doctor about all of the medicines you take, Ken shares about talking with his doctor after being diagnosed, Watch Dr. Nayak explain the importance of coming to your doctor with questions, Myra shares how she learned about her diagnosis, Joe describes being diagnosed and choosing ELIQUIS with his doctor, How AFib not caused by a heart valve problem can lead to a stroke. These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. They both require immediate medical attention. After activation, you can opt-out at any time by texting STOP to 69108. Learn more about the risk of developing an epidural blood clot while taking ELIQUIS. ELIQUIS and the ELIQUIS logo are trademarks of Bristol-Myers Squibb Company. You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as: Tell your doctor if you take any of these medicines. Please try again later. If you have kidney problems, Eliquis may build up in your body. For more information, see the Side effects explained section above. Warfarin-induced skin necrosis refers to a rare condition in which there is paradoxical blood clotting. People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Last medically reviewed on September 22, 2021. This offer is non-transferable, no substitutions are permissible, and offer cannot be combined with any other rebate/coupon, free trial, or similar, Bristol-Myers Squibb and Pfizer reserve the right to rescind, revoke, or amend. You can also see the Side effect specifics section above to read more. The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. Depending on the severity of the reaction, drug rashes may not necessarily be a cause for worry. If you have a bleeding problem or take other medications that can affect blood clotting, talk with your doctor about whether Eliquis is right for you. To the pharmacist: For processing assistance, please call McKesson Pharmacy Support at 1-866-279-4730. In clinical trials, side effects of Eliquis in older adults were similar to those in younger adults. Curious about drug rashes and what they look like? Please see U.S. Full Prescribing Information, including Boxed WARNINGS and MedicationGuide. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Eliquis increases the risk of bleeding. Having too much Eliquis in your body may increase your risk of side effects. These side effects may be temporary, lasting a few days to weeks. They can recommend ways to maintain a healthy weight. Bruising was a common side effect reported by people in studies of Eliquis. Cellulitis may also occur on the arm, breast, abdomen, and other areas. Eliquis hasnt been reported to cause other long-term side effects (side effects that last for a long time). ELIQUIS SIDE EFFECTS, USES, INTERACTIONS, PICTURES, WARNINGS & DOSING ELIQUIS QTY 60 5 MG Tablet Near 77381 Add to Medicine Chest Set Price Alert More Ways to Save APIXABAN (a PIX a ban) prevents or treats blood clots. Itching is common in many drug rashes. The Food and Drug Administration (FDA) has approved it to treat and help prevent certain dangerous blood clots. Eliquis may cause serious side effects. Use a gentle, natural soap and warm (but not too warm or hot) water to clean the rash. (2020). Blood clots block the blood vessels and cause necrosis, where an area of skin is destroyed. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Refill your prescription before you run out. (2021). Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. For a general overview of Eliquis, including details about its uses, see this article. Read on to learn about potential common, mild, and serious side effects. Stopping Eliquis isnt known to cause withdrawal symptoms. Most are minor and related to an increased risk of bleeding with this drug. Planned surgical, medical, or dental procedures. In some cases, the lesions may blister and fill with pus. This is a rare type of drug rash that can be life threatening. Apixaban is a rare cause of immune-complex small-vessel vasculitis. Weight gain wasnt reported in clinical trials of Eliquis. You are being redirected to a Bristol Myers Squibb corporate site. This medication can cause bleeding. Along with the causes of dark, Split nails are often caused by an injury such as a stubbed toe or receiving a severe blow to a finger or thumb. The clots location and severity will determine the treatment. Theyll likely recommend a medication other than Eliquis for your condition. Eliquis may not be right for you if you have certain medical conditions. None of it's unbearable (yet). Learn about causes, diagnosis, and more. 432-US-220045410/22. However, these side effects werent reported in clinical trials of Eliquis. Tell your doctor if you have any upcoming surgeries or dental procedures while youre taking Eliquis. Consult your doctor for more details. If you have kidney problems, your doctor may recommend a lower dose of Eliquis for you. This may include bleeding in organs such as the kidneys. Theproducts discussed herein may have different product labeling in different countries. Learn more here. An active ingredient is what makes a drug work. Try wearing loose clothing and reducing skin-to-skin friction in affected areas. Note that if youre taking Eliquis when you go into labor, you may have a risk of spinal blood clots if you receive epidural anesthesia for pain relief. Also, if you take Eliquis to help prevent blood clots after hip or knee replacement surgery, you may have reduced mobility both before and after the surgery. If you have any active bleeding, such as a bleeding stomach ulcer, your doctor will likely not prescribe Eliquis. 2005-2023 Healthline Media a Red Ventures Company. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. If you notice bruising during your treatment with Eliquis, talk with your doctor. The affected skin may be sensitive or painful, and severe cases can result in oozing sores, cracked skin or bleeding. You may hear this medication referred to as a blood thinner. For more information about Eliquis, including details about its uses, see this in-depth article.